Brain networks underlying infantile spasms associated with tuberous sclerosis complex


  • Connectivity between tuber locations and bilateral globi pallidi is associated with infantile spasms in children with tuberous sclerosis complex (TSC).

Why this matters ?

  • Studies exploring underlying neural correlates of infantile spasms in children with TSC (neurogenetic disorder) have yielded inconsistent results; as such, recent research is focusing on lesion-network mapping (LNM) to identify candidate associated networks.

  • The association of TSC-linked infantile spasms with specific brain networks may inform future treatment plans, potentially enhancing patient outcomes; however, further research is required for greater understanding of the pathology underlying these neural locations.