Brain perivascular spaces and severity of Huntington’s disease


  • Objective quantification of dilated subcortical perivascular spaces (PVS) observed on brain magnetic resonance imaging (MRI) in Huntington’s disease (HD) suggests that PVS burden is high in this condition, and is associated with disease severity.

Why this matters

  • The role of PVS (cerebrospinal fluid-filled extensions of the subarachnoid space) is linked to interstitial fluid drainage into the subarachnoid and perivascular spaces and glymphatic system, and studies show correlations between enlarged PVS and several neurodegenerative disorders.

  • The association between HD severity and PVS volume has potential implications for future therapeutic development and delivery since current delivery methods (e.g. intrathecal) may be negatively impacted by increased PVS volume; in addition, there may be a role for PVS volume as a potential imaging marker of HD disease severity.