Brain structural and functional alterations in patients with migraine without aura


  • The median raphe nuclei (MRN) play a role in the pathophysiology of migraine without aura (MwoA) during the interictal period, as assessed by structural and functional magnetic resonance imaging (MRI).

Why this matters

  • Studies using imaging techniques to assess migraine have increased; however, most focus on either structural or functional MRI for assessment as opposed to both in tandem, or focus only on specific regions when combining techniques rather than the whole brain.

  • Functional connectivity (FC) involving the MRN in people with MwoA may serve as the basis for further confirmatory investigation, for comparison studies assessing migraine with aura, or to support development of targeted therapies aimed at optimizing patient outcomes.