Brains of patients with AD show altered protein (but not RNA) expression

New research shows that proteomic changes in the brains of patients with Alzheimer’s disease (AD) correlate with disease pathology but may not be observable at the RNA level.

“The biological processes that are disrupted in the AD brain are incompletely understood,” said Dr Erik Johnson of Emory University in Atlanta, Georgia, USA. “We recently performed a proteomic analysis of more than 2,000 brains to better understand these changes. It highlighted alterations in astrocytes and microglia as likely key drivers of disease.”