Breathing dysfunction in epilepsy: how does our biology work to prevent it?


  • Raised serum serotonin (5-HT) is associated with lower rates of ictal central apnea (ICA), and post-convulsive central apnea (PCCA) in individuals with epilepsy.

Why this matters

  • Sudden unexpected death in epilepsy is a leading cause of mortality among people with neurologic disorders.

  • Understanding the biological mechanisms that act to protect against it is essential to developing preventive strategies.