Bridging the gap between microstructural and morphological associations in temporal lobe epilepsy


  • Utilization of a novel resting state-functional MRI (rs-fMRI) in temporal lobe epilepsy (TLE) may aid in the profiling of functional connections across the entire cortical mantle thus improving understanding of the field and diagnostic and interventional procedures.

Why this matters

  • TLE is the most common drug-resistant epilepsy in adults and the most responsive to surgical intervention. Despite this, functional anomalies and their link to underlying structural alterations remain incompletely understood.

  • Greater understanding of the connectopathy in TLE may advance knowledge of the mechanisms giving rise to temporal lobe seizures, improve patient-specific diagnostic procedures, and guide surgical prognostics.