Calcium sensitivity maintains specific force of muscle in facioscapulohumeral muscular dystrophy

Takeaway

  • Clinical muscle weakness in facioscapulohumeral muscular dystrophy (FSHD) is not caused by reduced specific force of individual muscle fibers, which is maintained by increased calcium sensitivity in severely affected tissue with fatty infiltration.

Why this matters

    Increasing the understanding of the pathophysiology underlying the development of clinical muscle weakness in people with FSHD will help identify future therapeutic targets.