Can mild cognitive impairment be classified into meaningful subgroups ?

Takeaway

  • Using actuarial methods, patients were classified into subtypes of mild cognitive impairment (MCI) or cognitively normal (CN). These were associated with different cognitive profiles, clinical outcomes, and neuropathological findings.

Why this matters ?

  • Diagnosis of MCI relies on interpretation of an individual’s symptoms and cognitive test results, which is largely subjective.

  • Data-driven methods may be useful in producing reliable cognitive phenotypes that can be included in clinical trials and used to predict future outcomes.