Can the revised functional rating scale accurately predict upper limb function in all ALS subsets?


  • The revised functional ALS rating scale (ALSFRS-R) is a useful tool to evaluate upper limb (UL) function in ALS; however; hand dominance should be considered as the ALSFRS-R may be misleading in right-handed patients with initial left upper limb (LUL) onset.

Why this matters

  • Functionality in ALS is measured by ALSFRS-R; however, several pitfalls have been reported with this scoring method. The impact of UL-onset side on ALSFRS-R is currently unknown.