CARE trial study design: assessing safety and efficacy in recurrent head and neck cancer


  • A single-center prospective study design is described, assessing the safety and efficacy of carbon ion reirradiation (reCIRT) compared with standard-of-care intensity-modulated re-radiotherapy (reIMRT) in recurrent head and neck cancer (rHNC).

Why this matters

    Retrospective studies indicate that reCIRT may be a more tolerable treatment option for rHNC compared with reIMRT; however, this is the first randomized prospective trial to compare the treatments.