The observed decrease in serum uric acid (UA) level in patients with MS is simply an effect of the MS disease attack and not a cause of the disease itself.
Why this matters
Meta-analysis of data taken from case-control studies revealed that serum UA is lower in patients with multiple sclerosis (MS) compared to healthy controls and may represent a deficiency in protection against oxidative stress.
Whether there is a causal link between genetically determined serum UA level and the risk of MS remains elusive.
Mendelian randomization (MR) can be applied to determine the causal link between serum UA level and the risk for MS.