Causal association of serum uric acid level on risk of MS


  • The observed decrease in serum uric acid (UA) level in patients with MS is simply an effect of the MS disease attack and not a cause of the disease itself.

Why this matters

  • Meta-analysis of data taken from case-control studies revealed that serum UA is lower in patients with multiple sclerosis (MS) compared to healthy controls and may represent a deficiency in protection against oxidative stress.

  • Whether there is a causal link between genetically determined serum UA level and the risk of MS remains elusive.

  • Mendelian randomization (MR) can be applied to determine the causal link between serum UA level and the risk for MS.