CD8 T cell infiltration is paralleled to synucleinopathy and neuronal death in Parkinson’s disease

Takeaway

  • This study suggests that CD8 T cells may contribute to nigral dopaminergic neuron dysfunction and death in Parkinson’s disease.

Why this matters

  • Parkinson’s disease is the second most frequent form of neurodegenerative disease and is caused mainly by the loss of neuromelanin-containing neurons in sustantia nigra pars compacta (SNpc).

  • Several neuron autonomous and non-neuron autonomous mechanisms have been suggested to contribute to neuronal death, however, there currently remains no evidence to support any one of these mechanisms.