Cerebral small vessel disease pathology and Parkinson’s disease motor phenotypes


  • Deep white matter hyperintensities (DWMH) in the frontal and occipital lobes is an independent risk factor for the postural instability and gait disability (PIGD) motor phenotype in Parkinson’s disease (PD).

Why this matters

  • The correlation between DWMH and PIGD indicates that vascular pathology may contribute to the PIGD motor phenotype and thus alternative non-dopaminergic therapeutic strategies may be appropriate.