Cerebral white matter degeneration in amyotrophic lateral sclerosis linked to clinical progression

Takeaway

  • Progressive decline in the fractional anisotropy of people with amyotrophic lateral sclerosis is linked to clinical disease progression.

Why this matters

    These findings could facilitate the development and validation of fractional anisotropy as a non-invasive and sensitive biomarker for cerebral white matter degeneration in amyotrophic lateral sclerosis.