Cerebrospinal fluid biomarkers linked to risk factors for Alzheimer’s disease in pre-dementia


  • People without dementia can be subdivided into two subgroups based on the combination of β-amyloid 42 and total and hyperphosphorylated tau in cerebrospinal fluid. 

Why this matters

    These findings are important because they suggest that cerebrospinal fluid biomarkers should not be interpreted in isolation. Participants in the second subgroup have known risk factors for Alzheimer’s disease dementia and should be closely monitored.