Cerebrospinal fluid neurofilament light protein as a marker of cognitive decline

Takeaway

  • High levels of cerebrospinal fluid neurofilament light (CSF NFL) protein is associated with cognitive decline in people with Alzheimer Disease (AD) and frontotemporal dementia (FTD).

Why this matters

  • CSF NFL could help facilitate early diagnosis, determine disease severity and prognosis in neurodegenerative disorders.