Cerebrospinal neurofilament light chain protein levels predict severity of Parkinson’s disease

Takeaway

  • Neurofilament light chain protein levels in cerebrospinal fluid are linked to disease severity and predict survival in Parkinson’s disease.

Why this matters

    There is currently no validated neurochemical biomarker in Parkinson’s disease to measure disease activity and predict prognosis. These important findings suggest that neurofilament light chain protein levels in cerebrospinal fluid reveal the intensity of the neurodegenerative process, which could help with the selection of participants for future clinical trials.