Vascular brain injury and hippocampal volume were associated with an increased rate of cognitive decline independent of amyloid status in cognitively normal older adults.
Why this matters
As people age, amyloid accumulation increases and is associated with decreasing cognition; however, not all people with declining cognitive abilities have amyloid deposits.
Cerebrovascular disease (CVD) is also associated with cognitive decline; however, the mechanism by which this occurs is unclear. Understanding the effects of CVD and amyloid in the brain may lead to early treatment and improve clinical outcomes for older adults.