Cerebrovascular effects on cognition in normal older adults regardless of amyloid status


  • Vascular brain injury and hippocampal volume were associated with an increased rate of cognitive decline independent of amyloid status in cognitively normal older adults.

Why this matters

  • As people age, amyloid accumulation increases and is associated with decreasing cognition; however, not all people with declining cognitive abilities have amyloid deposits.

  • Cerebrovascular disease (CVD) is also associated with cognitive decline; however, the mechanism by which this occurs is unclear. Understanding the effects of CVD and amyloid in the brain may lead to early treatment and improve clinical outcomes for older adults.