Changes in cerebral perfusion in genetic frontotemporal dementia

Takeaway

  • Arterial spin labeling MRI shows differences in cerebral blood flow in pre-symptomatic carriers of mutations commonly associated with genetic forms of frontotemporal dementia.

Why this matters

  • Measurement of cross-sectional differences in cerebral blood flow with arterial spin labeling MRI may provide a promising, non-invasive imaging biomarker for the pre-symptomatic stages of genetic frontotemporal dementia.