Significant thinning of the peripapillary retinal nerve fiber layer (pRNFL), alterations in retinal microvasculature, and reduced visual acuity were observed in individuals with neuromyelitis optica spectrum disorder (NMOSD) before an episode of optic neuritis (ON).
Why this matters
Recent studies have shown that neurons within the macula can degenerate in individuals with NMOSD without ON. Macular vascular damage after NMOSD has also been associated with clinical data. Therefore, the retinal microvasculature may be an indicator of retinal pathology in NMOSD. The results of this study may help to further understand how microvasculature changes in the retina are associated with the pathology of NMOSD.