Characteristics of individuals with late- and very late-onset neuromyelitis optic spectrum disorder


  • Individuals with very late-onset neuromyelitis optic spectrum disorder (VLO-NMOSD) had a poorer prognosis compared with individuals with late-onset NMOSD (LO-NMOSD).

Why this matters

    NMOSD is an auto-immune disease of the central nervous system. Onset of NMOSD generally occurs in individuals aged 30–40 years, but due to improvements with diagnostic techniques, older individuals have been increasingly diagnosed. Individuals who experience onset of NMOSD between 50–70 years of age are characterized as LO-NMOSD; individuals who experience onset after 70 years of age are considered as VLO-NMOSD. Clinical characteristics between individuals with LO-NMOSD vs VLO-NMOSD are different. The results of this study provide some insight on the factors which affect the prognosis of NMOSD among individuals with VLO-NMOSD.