Six fusion events in five primary meningiomas were identified. All five gene fusions resulted in loss of function, including the tumor suppressor gene NF2, and other genes known to be involved in meningioma biology, such as PHF19 and NOTCH3.
Why this matters
Meningiomas are the most common primary intracranial tumor and cluster into three types: A, B and C, characterized by progressively worsening clinical course.
Gene fusion events have been identified to play a crucial role in other tumors of the central nervous system but has not been well characterized in meningiomas. Although gene fusions are rare in meningiomas, they are more likely to be found in tumors with greater genomic instability.