Characterization of microinfarcts and microbleeds in cerebral amyloid angiopathy

Takeaway

  • Imaging and histopathology reveal that distinct processes seem to contribute to ischemic lesions (IL) and hemorrhagic lesions (HL) in cerebral amyloid angiopathy (CAA).

Why this matters

  • CAA is characterized by amyloid b (Ab) in cortical arterioles, associated with IL (microinfarcts [mINF]) and HL (microbleeds [mBL]) and common in older individuals.

  • Better understanding of pathophysiologic relationships among mINF, mBL, and CAA severity may improve treatment.