Characterization of probable nonoptic pathway tumors in children with neurofibromatosis type 1

Takeaway

  • In this study in children with neurofibromatosis type 1 (NF1), probable nonoptic pathway tumors (non-OPTs) developed in the majority of participants which progressed both clinically and radiographically, especially in deep extensive tumors.

Why this matters

    Characterization of non-OPTs in children with NF1 indicates deep extensive tumors are particularly aggressive, will necessitate special attention by clinicians, and likely require multiple rounds of tumor-directed therapy.