Characterization of symptom improvement and connectivity profiles in deep brain stimulation


  • During subthalamic nucleus (STN) deep brain stimulation (DBS), connectivity of the ipsilateral ascending cerebellothalamocortical pathway but not the descending corticopontocerebellar pathway substantially improved symptoms of bradykinesia in Parkinson’s disease (PD).

Why this matters ?

  • This characterization of connectivity profiles to improve symptoms of bradykinesia along with characterization of profiles alleviating rigidity and tremor in PD may assist in improving target-planning in STN DBS.