Characterizing functional connectivity in post-traumatic headache


  • Patients with mild traumatic brain injury (mTBI) experiencing post-traumatic headache (PTH) have differences in static (sFNC) and dynamic (dFNC) functional connectivity compared to patients with no PTH, and these could be useful biomarkers for predicting which mTBI patients will experience PTH.

Why this matters ?

  • PTH is a common and highly burdensome feature of mTBI, with a prevalence of up to 79% at 3 months post-injury and 65% at 12 months. However, the biological mechanisms underlying PTH remain unclear.

  • Previous studies have found changes in functional connectivity in headache disorders and mTBI; it is possible that network alterations could help to explain PTH. A thorough characterization of static and dynamic network connectivity is warranted.