Chronic constriction sciatic nerve injury and cognition: an animal neuropathic pain model


  • The adapted chronic constriction injury (CCI) neuropathic pain model using a single ligature around the sciatic nerve induces affective, sensory, cognitive and motor alterations comparable to the established CCI model using four ligatures, without autotomy.

Why this matters

  • Chronic constriction injury is an animal model of neuropathic pain, induced via sciatic nerve ligation which reproduces the main human sensory symptoms in this condition, including mechanical allodynia, and chemical and thermal hypersensitivity.
  • The development of an appropriate and easily reproducible neuropathic pain model to study underlying mechanisms may be beneficial for the development of targeted treatments for this condition and potentially its neuropsychiatric comorbidities.