Concomitant brainstem lesions were associated with a worsened prognosis in individuals with myelin oligodendrocyte glycoprotein antibody disease (MOG-Ab) who experienced a transverse myelitis (TM) episode, while in individuals with aquaporin-4 (AQP4) disease older age was associated with higher disability scores.
Why this matters ?
MOG-Ab is a disease characterized by TM with associated disability appearing after a TM episode. MOG-Ab is often misdiagnosed as neuromyelitis optica spectrum disorder, a disease also characterized by TM but is distinguished by the presence of AQP4 antibodies. This study helps recognize the differences in TM caused by MOG-Ab versus AQP4-Ab to enable better clinical treatment for both individuals.