Clinical phenotype of autoimmunity to neuronal B2 form of adaptor protein–3

Takeaway

  • Autoimmunity to the neuronal B2 form of adaptor protein–3 (AP3B2) is rare and characterized by sensory and/or cerebellar ataxia.

Why this matters

  • The clinical phenotype of AP3B2 autoimmunity indicates it should be considered during differential diagnosis of patients with myeloneuropathy or mixed cerebellar and sensory ataxia.