Clinical practice guidelines update of cytoreductive surgery in newly diagnosed glioblastoma


  • Analysis of recent literature continues to support maximal extent of resection to preserve neurological function in patients with newly diagnosed glioblastoma.

Why this matters

  • Surgical resection is a common approach for the treatment of newly diagnosed glioblastoma in combination with other treatment modalities.

  • Cytoreductive surgery allows for maximal safe surgical resection while preserving preoperative neurological function.

  • Increasing the extent of resection has prolonged patient survival and has prompted investigation of supramaximal or supratotal resection. This update will also analyse the role of advanced intraoperative guidance techniques for maximising extent of safe resection.