Clinical response to deep brain stimulation depends on structural connectivity in Tourette syndrome

Takeaway

  • Structural connectivity of the site of deep brain stimulation plays a key role in facilitating symptom improvement in Tourette syndrome.

Why this matters

    The structural networks identified here could enhance current neuromodulation targets for Tourette syndrome by helping to guide deep brain stimulation targeting. Specific targeted modulation could improve tics and comorbidities in people with severe, treatment-refractory symptoms.