Clinically isolated syndrome or migraine with aura? A new diagnostic facilitator


  • A greater number and volume of white matter hyperintensities (WMH) in the periventricular region of the brain is indicative of clinically isolated syndrome (CIS) versus migraine with aura (MA).

Why this matters ?

  • CIS ­– a feature of multiple sclerosis – is often misdiagnosed as MA during radiological examinations; this study identifies regional differences in WMH presence that could facilitate accurate diagnosis.