Clostridium bolteae and neuromyelitis optica spectrum disorder in Indian patients


  • Elevated levels of clostridium bolteae (C. bolteae) were associated with aquaporin 4 IgG antibody positive (AQP4+) neuromyelitis optica spectrum disorders (NMOSDs) among Indian patients.

Why this matters

  • The intestinal microbiota is an environmental factor that may play an important role in the initiation and progression of autoimmune disorders such as NMOSD; while there are few studies exploring this, findings suggest a strong association of microbiota and AQP4+ NMOSD patients specifically.

  • The suggestion of a link between C. bolteae and NMOSD provides additional evidence of the gut/autoimmunity connection, and warrants further investigation for potential development of therapies with probiotic components, which may alleviate symptoms and boost the immune system in susceptible individuals, possibly reducing disease risk.