Cognitive and language outcomes for children with hemimegalencephaly treated with hemispherectomy


  • Language milestones remain significantly delayed in children with hemimegalencephaly (HME) and drug-resistant seizures despite hemispherectomy.

Why this matters

  • HME is a rare congenital malformation wherein one half of the brain is abnormally larger than the other, resulting in seizures, motor symptoms, and developmental delay.

  • Hemispherotomy is used in children with drug-resistant seizures and is effective in 60–85% of cases. Although there is some evidence that hemispherotomy also improves non-seizure outcomes, previous studies have been limited by small samples sizes or poor reporting.

  • A thorough assessment of the impact of hemispherotomy on language and cognitive outcomes in children with HME is warranted.