Cognitive and physical fatigue represent distinct domains of fatigue in multiple sclerosis


  • Cognitive and physical fatigue are associated with distinct problems in daily functioning, which impact differentially on role fulfilment and quality of life (QoL) in multiple sclerosis (MS); as such, these two types of fatigue should be considered distinct domains of the fatigue experience in MS.

Why this matters

  • Traditionally, fatigue was regarded as a unidimensional construct; this study is the first to document the varied impact of cognitive and physical fatigue on daily functioning and QoL, and could help to inform clinical judgements on optimizing care in people with MS.