Cognitive decline and vascular risk factors in preclinical Alzheimer’s disease

Takeaway

  • Lifestyle and vascular factors such as obesity and hypertension are associated with changes in cerebrospinal fluid (CSF) tau levels and cognitive scores in preclinical Alzheimer’s disease (AD) individuals.

Why this matters

  • Understanding the associations between risk factors in healthy individuals and AD biomarkers (total tau [t-tau], phosphorylated tau [p-tau] and amyloid) can help develop primary and secondary prevention strategies and improve timely and accurate prognosis.