Cognitive decline in patients with Parkinson’s disease is not linked to caudate nucleus penetration


  • Retrospective analysis of adverse cognitive changes in patients with Parkinson’s disease (PD) who recently underwent deep brain stimulation (DBS) of the subthalamic nucleus (STN) shows no causal link with electrode trajectory.

Why this matters

  • Unpredictable nature of post-operative cognitive decline in selective patients necessitates a thorough understanding of the risks of electrode penetration of the caudate nucleus to establish an effective therapeutic strategy.