Cognitive deficits in neuromyelitis optica spectrum disorder – involvement of the hippocampus


  • Patients with aquaporin-4 (AQP4)-positive neuromyelitis optica spectrum disorder (NMOSD) had significant hippocampal atrophy that was associated with verbal and visual memory impairment, but not attentive or executive function.

Why this matters

  • Cognitive impairment has been reported in up to 70% of patients with NMOSD, a rare autoimmune condition that affects the spinal cord and optic nerves.

  • Determining the underlying pathology of cognitive impairment in these patients – which has not been well studied – will contribute to the future development of effective therapeutic interventions.