Cognitive heterogeneity identified in different clusters of early-onset Alzheimer’s disease


  • Two distinct clusters of patients with early-onset Alzheimer’s disease (EOAD) were identified: C1 is an amnestic/typical phenotype and C2 is a non-amnestic/atypical phenotype characterized by greater impairments in executive functions, language, and visuospatial abilities; the groups differ in other genetic and non-genetic factors and cognitive decline.

Why this matters

    Different phenotypes exist in Alzheimer’s disease (AD), but little is known about clinical characteristics and cognitive decline in these groups. Results from this study show that cluster analysis may be useful in characterizing clinical heterogeneity in AD, having important implications for clinical trials and treatment protocols.