Cognitive performance in multiple sclerosis linked to APOE ε4 homozygosity and disease burden

Takeaway

  • In people with clinically isolated syndrome (CIS) or relapsing-remitting multiple sclerosis (RRMS), parameters of higher disease burden and APOE ε4 homozygosity may predict cognitive performance.

Why this matters

    Understanding APOE as a possible risk factor for cognitive changes in multiple sclerosis may provide a possible target for development of future treatments.