Cognitive profile and markers of AD-type pathology in Lewy body dementias


  • There is a suggested association between Alzheimer’s disease (AD)-type co-pathology markers and impaired language performance in patients with Lewy body dementias (LBDs).

Why this matters ?

  • LBDs (dementia with Lewy bodies [DLB] and Parkinson’s disease dementia [PDD]) are characterized by progressive cognitive and motor deficits; and are associated with clinical definition inconsistency, possibly due to differences in underlying pathology, including AD-type co-pathology.

  • The link between impaired language performance and AD-type co-pathology in LBDs suggests potential pathology-specific clinical presentation, and highlights the need for future investigation with more comprehensive cognitive testing for validation, in addition to longitudinal study to explore disease progression-related effects.