Cognitive reserve mitigates the genetic risk of dementia


  • Promoting cognitive reserve through a lifelong engagement in reserve-enhancing activities attenuates the risk of dementia, particularly in subpopulations with a high genetic risk.

Why this matters

  • The interaction between lifelong cognitive reserve and genetic predisposition to dementia remains poorly understood; carriers of the apolipoprotein ε4 (APOE-ε4) allele might particularly benefit from the cumulative effects of mental- and social-related activities across the entire life course.