Cognitive, structural and functional brain changes over time in Korsakoff’s Syndrome


  • Structural and metabolic changes in the Papez circuit (PC) persist over time in individuals with Korsakoff’s Syndrome (KS), in accordance with the irreversible nature of amnesia.

Why this matters

  • The Papez and frontocerebellar (FCC) circuits are known to be affected in KS (neurocognitive disorder induced by alcohol abuse and characterized by severe anterograde amnesia); however, there is a paucity of data assessing longitudinal changes in this cohort.

  • The persistent deficits seen in KS patients highlight the KS-characteristic neural changes underlying permanent anterograde amnesia; and may contribute to management of these patients, as well as development of educational tools to inform individuals with alcoholism about this complication.