In the treatment of adult malignant gliomas (MG) using stereotactic radiosurgery (SRS), outcomes appear to be comparable for fractionated SRS (fSRS) and single-session SRS (sSRS).
Why this matters
Optimal radiation dosing and avoidance of radiation-associated toxicities (RAT) are important when using SRS to treat recurrent MG.
Effective and safe radiation treatment of MG using sSRS is limited by tumor volume.
Divided radiation dosing (fSRS) may facilitate delivery of adequate radiation doses without increased RAT for treatment of large tumors.