Comparing fractionated and single session stereotactic radiosurgery for malignant gliomas


  • In the treatment of adult malignant gliomas (MG) using stereotactic radiosurgery (SRS), outcomes appear to be comparable for fractionated SRS (fSRS) and single-session SRS (sSRS).

Why this matters

  • Optimal radiation dosing and avoidance of radiation-associated toxicities (RAT) are important when using SRS to treat recurrent MG.

  • Effective and safe radiation treatment of MG using sSRS is limited by tumor volume.

  • Divided radiation dosing (fSRS) may facilitate delivery of adequate radiation doses without increased RAT for treatment of large tumors.