Comparison of cell-based assays for detection of myelin oligodendrocyte-immunoglobulin G antibodies

Takeaway

  • There was a high degree of concordance across three different myelin oligodendrocyte-immunoglobulin G (MOG)-immunoglobulin G (IgG) cell-based assays (CBAs: Euroimmun fixed, Oxford live cell and Mayo live cell fluorescence-activating cell sorting).

Why this matters

  • The results provide confidence that positive results in these assays are more reliable indicators of MOG spectrum disorders (acute disseminated encephalomyelitis [ADEM], neuromyelitis optica [NMO], optic neuritis, and transverse myelitis).