Connectivity analyses for detection of network changes in early multiple sclerosis


  • Patients with a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) had abnormal connectivity-based nodal strength and network modularity compared with healthy volunteers.

  • Connectivity analyses based on multi-shell imaging can detect potentially relevant network changes in early MS, differentiate patients at very early stages of MS from healthy volunteers, and may be potential biomarkers in early MS.

Why this matters

  • High quality tractography is needed to understand the pathology of MS; however, there are limitations with the methods currently used.

  • Multi-shell diffusion magnetic resonance imaging (MRI) for the production of brain connectivity metrics is a new strategy that has not been investigated for patients with early MS.