Coronary microvascular dysfunction causes blunted coronary flow reserve in CADASIL

Takeaway

  • Reduced coronary flow reserve (CFR) is observed in people with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) due to coronary microvascular dysfunction (CMD), independent of brain lesion burden or cognitive function.

Why this matters

    CADASIL is a systemic disease of the microcirculation, and active monitoring and lifestyle changes should be considered.