Correlating cortical magnetic resonance imaging results and histopathology in multiple sclerosis

Takeaway

  • Patterns of axonal loss may underlie differences in magnetic resonance imaging (MRI) results in demyelinated and normal-appearing cortex in patients with multiple sclerosis (MS).

Why this matters

  • Identification of histopathologic features associated with diffusion tensor (DT) MRI changes could lead to new markers for monitoring MS progression.