Correlating pathology with clinical presentation in patients with frontotemporal dementia


  • Psychiatric symptoms such as hallucination may indicate specific molecular pathologies of frontotemporal lobar degeneration (FTLD); the authors suggest neuropsychiatric symptoms should be routinely examined in patients with frontotemporal dementia (FTD).

Why this matters

  • FTD is a clinical diagnosis which covers a group of diverse neurodegenerative disorders, including behavioral variant of FTD and primary progressive aphasia. Diagnosing FTD is challenging due to the varied clinical presentations and a lack of biomarkers.

  • FTLD is a pathological diagnosis based on neuroanatomical imaging and the presence of molecular aggregates like TDP-43, tau and FUS.

  • Although some patients with FTD also have FTLD pathology, other patients do not.

  • Finding relationships between the clinical presentation and underling molecular pathology of FTD and FTLD would improve understanding of these conditions.