Correlating the genetic variations of the prominin 1 gene with retinal degeneration phenotype

Takeaway

  • Differences in the onset and severity of inherited retinal degeneration were observed between recessive and dominant variants of the prominin 1 (PROM1) gene.

Why this matters

  • Understanding the association between genetic variants of PROM1 and retinal degeneration phenotype is important for developing optogenetics and future gene-based therapies.